Metal-organic Frameworks (MOFs)
A Hidden Battle Within the Body
Despite significant advancements, organ transplantation remains one of the most complex and challenging medical treatments, requiring deep knowledge of how the immune system interacts with transplanted organs. In general, by inhibiting T-cell activation pathways and reducing the production of harmful antibodies, transplant rejection can be prevented, and immunological tolerance can be strengthened. This approach is particularly important in critical stages of the immune response, including T-cell differentiation, function, and interactions with other immune cells.
According to Mohamed Sayegh, the most fundamental question in this field is: “What are the mechanisms of immunological tolerance, and how can we trick the immune system into accepting a foreign organ without rejection and without immunosuppression?”